Abstract




 
   

IJE TRANSACTIONS A: Basics Vol. 32, No. 4 (April 2019) 460-466    Article in Press

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  PLANT-BASED CALCIUM FRUCTOBORATE AS BORON-CARRYING NANOPARTICLES FOR NEUTRON CANCER THERAPY
 
F. Pirouz, G. Najafpour, M. Jahanshahi and M. Sharifzadeh Baei
 
( Received: January 13, 2019 – Accepted: March 07, 2019 )
 
 

Abstract    Boron neutron capture therapy (BNCT) is an effective clinical method in cancer treatment based on fission reactions and nuclear capturing. In this method, use of the best boron-containing agents for boron therapy and boron delivery agent for transfer to the infectious site are the key points for efficienct treatment. Our research indicated that calcium fructoborate(CF) was the best compound as a boron-containing agent for boron therapy. Furthermore, studies have demonstrated that liposomes can selectively and effectively deliver large quantities of boron to cells and that the compounds delivered by liposomes have a longer cell retention time. Indeed, liposomal encapsulation technology of CF as nanostructured liposome carriers (NLCs) was extensively evaluated due to the ability of these nano-vehicles for the delivery of boron compounds. In this work, the molecular composition of the CF used as a carrier supplement for cancer therapy is deeply investigated. FTIR, XRD, TG, DSC and Raman spectroscopic analyses were used for the characterization of the carrier. The experimental measurements agreed very well with the molecular formula of Ca[(C6H10O6)2B]24H2O.

 

Keywords    Boron Neutron Capture Therapy; Calcium Fructoborate; Liposome Encapsulation

 

چکیده   

روش درمان با گیر انداختن نوترون در بور (BNCT) یکی از روش های موثر در درمان سرطان بر اساس واکنش های همجوشی و تسخیر هسته ای است. در این روش، استفاده از بهترین ماده حاوی بور به منظور درمان به روش بور و انتخاب بهترین عامل حامل بور به منظور انتقال آن به جایگاه عفونت، از نکات کلیدی به منظور یک درمان موثر است. تحقیقات ما نشان داد که ترکیب کلسیم فروکتوبورات (CF) بهترین ترکیب به عنوان یک ماده حاوی بور برای بور درمانی است. علاوه بر این، مطالعات نشان داده است که لیپوزوم ها می توانند به طور موثر و انتخابی مقادیر زیادی از بور را به سلول ها منتقل کنند و ترکیباتی که توسط لیپوزوم ها منتقل می شوند، می توانند مدت زمان طولانی تری در سلول ها بمانند. در واقع، تکنولوژی کپسول سازی لیپوزومی CFبه علت توانایی این نانووسیله در انتقال ترکیبات حاوی بور به عنوان یک نانوساختار حامل لیپوزومی (NLCs) به طور گسترده ای مورد بررسی قرار گرفته است. در این مقاله، ترکیب مولکولی CFکه به عنوان یک عامل رسانش جایگزین برای درمان سرطان مورد استفاده قرار گرفته است، به طور گسترده مورد بررسی قرارگرفته است. تجزیه و تحلیل اسپکتروسکوپیFT-IR ، XRD،TG ، DSCو رامان اسپکتروسکوپی برای تشخیص ساختار ترکیب حامل بور انجام شده است. اندازه گیری های تجربی با دقت بسیار خوبی فرمول مولکولی Ca ([C6H10O6] 2B] 24H2O را برای ساختار موردنظر تایید نموده اند.

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